7TH Course CHALLENGES AND PROSPECTS OF NANOMEDICINE FOR BRAIN TARGETING

 

Erice, Italy, 1-5 JULY 2024

 

Monday  July 1 - ARRIVALS

 

Tuesday July 2

 

09:00 - 09:30  Opening remarks on behalf of School Director: Prof. Massimo Masserini

Welcome by Course Director: Prof. Francesca Re

Practical instructions: Dr. Silvia Sesana

 

SESSION I:  Blood-brain barrier models and alternative approaches for crossing

Chair: M. Masserini, S. Sesana

 

09:30 - 10:30 Marie-Pierre Dehouck (University of Artois, France) Establishing and using in vitro blood-brain barrier models

10:30 - 10:45 Mario Micali (University of Rome Tor Vergata, Rome, Italy) PULSAR: Predictive Ultrasound Localization and Skull Aberration Reference for animal model experiments

10:45 - 11:15 Coffee Break

11:15 - 11:30   Kravicz Marcelo (University Milano-Bicocca, Italy) Functionalised liposomes for automated fluorine-18 surface radiolabelling and in vivo PET imaging

11:30 - 12:30 Maria Anna Deli (Institute of Biophysics, Szeged, Hungary) History of the in vitro BBB models from the first cell cultures to organ-on-chip models

12:30 - 14:30 Lunch break

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SESSION II:  Blood-brain barrier alterations in human brain disorders and alternative approaches for crossing

Chair: G. Sierri F. Sica

 

14:30-15:30 Anna Dimberg (Uppsala University, Sweden) Vascular abnormalities in glioblastoma, blood-brain-barrier breakdown and beyond

15:30 - 15:45 West Kristian Paraiso (Universitat Internacional de Catalunya, Spain) Modulating energy balance using a nanomedicine platform targeting brain lipid metabolism

15:45 - 16:00 Camilla Paolini (University Milano-Bicocca, Italy) Oxytocin promotes blood-brain barrier formation in a mouse model of autism spectrum disorder and schizophrenia

16:00-16:30 Coffee Break

16:30 - 16:45 Syed Bilal Nizami (University of Rome Tor Vergata, Italy) Focused Ultrasound for Smart Magnetic Materials Delivery to the Brain

16:45 - 17:45 Franzisca Richter (University of Veterinary Medicine Hannover, Germany) Nanoparticle-mediated nose to brain microRNA delivery for treatment of Parkinson’s disease

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Wednesday  July 3

 

SESSION III – New strategies to cross the blood-brain barrier

Chair: Patrucco, Fontanini

 

09:00 - 10:00 Marzia Bedoni (IRCCS Fondazione Don Carlo Gnocchi, Milan, Italy) Biophotonics for the Characterization of Liposomes ​for Glioblastoma and Alzheimer’s Disease treatment

10:00 - 10:15 Zhancun Bian (Aix Marseille University, France) Bola-amphiphilic glycodendrimers for targeting blood-brain barrier

10:15 - 10:30 Aleksandra Predeina (Istituto Italiano di Tecnologia, Genova, Italy) Metal-organic Framework-based Magnetic Composites as Drug Delivery System for Cancer Treatment

10:30 - 11:00 Coffee Break

11:00 - 11:15 Abdechakour Elkihel (Aix Marseille University, France) Dynamic self-assembling dendrimer nanosystems to target neuroinvasive pathogens

11:15 - 12:15 Bruno Sarmento (i3S, University of Porto, Portugal) Modulation of Pharmacokinetics of Multiple-targeting Nanomedicines for Brain Disorders Crossing the Blood-Brain Barrier

12:15 - 14:30 Lunch

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SESSION III – New strategies to cross the blood-brain barrier

Chair: M. Kravicz, S. Comi

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14:30 - 15:30 Kalimandeer K. Singh (University of Central Lancashire, United Kingdom) Designing Nanomedicine for overcoming blood brain barrier for targeted glioblastoma therapy

15:30 - 15:45 Marion Le Meur (IMDEA Nanociencia, Spain) Nanoparticles to target the circadian clock in Alzheimer’s disease: optimization of brain penetration

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SESSION IV- Smart nanotechnologies for therapy of neurodegenerative diseases and brain tumours 

Chair: M. Kravicz, S. Comi

 

15:45 - 16:00 Franciely de Rufino Almeida Lima (Preto University of São Paulo - Brasil) Therapeutic strategy development, characterization, and in vitro antitumor activity evaluation in glioblastoma

16:00 - 16:30 Break

16:30 - 17:30 Gianni Ciofani (Istituto Italiano di Tecnologia, Pontedera, Italy) Piezoelectric nanotransducers for brain cancer therapy and neuronal stimulation

20:00 SOCIAL DINNER

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Thursday  July 4

 

SESSION IV - Smart nanotechnologies for therapy of neurodegenerative diseases and brain tumours 

Chair: D. Ferrario, F. Re

 

09:00 - 10:00 Francois Lux (Université de Lyon, France) How to translate an ultrasmall hybrid nanoparticle to the clinic: AGuIX nanoparticles as an example.

10:00 - 10:15 Francesca Giulimondi (Sapienza, University of Rome, Italy) Apolipoproteins-enriched nucleoproteic corona enhances effective gene delivery in brain cancer 3D models

10:15 - 10:30 Erica Quagliarini (Sapienza, University of Rome, Italy) Bio-coronated liposomal Temozolomide mitigates growth in 3D brain tumor models

10:30 - 11:00 Coffee Break

11:00 - 12:30 POSTER SESSION - Jiri Drab and Tana Zavodna, Sebastiano Micocci, Sahel Ghasemzadeh, Francesco Saverio Sica and Michela Patrucco, Veronica Fontanini

12:30 - 14:30 Lunch Break

 

SESSION IV - Smart nanotechnologies for therapy of neurodegenerative diseases and brain tumours 

Chair: Masserini, Re

 

14:30 - 15:30 Ramassamy Charles (Institut National Recherche Scientifique, Canada) Comparative analysis of polymeric nanoparticles and extracellular vesicles as nanocarrier-based drug delivery systems: towards optimizing therapeutic efficacy for Alzheimer's disease therapy

15:30 - 15:45 Giulia Sierri (University Milano-Bicocca, Italy) Nanoparticle’s shape is the game-changer for a customized delivery through tunneling nanotubes among glioblastoma cells

 

16:00 – CONCLUSION

 

Friday July 5- DEPARTURES