International School of Nanomedicine
School Directors Massimo Masserini & Mauro Ferrari
Ettore Majorana Foundation and Center for
Scientific Culture
ERICE (Sicily) – Italy
​Organizational Secretariat: Silvia Sesana
e-mail: nanomedicine.school@unimib.it
1-5 July 2024
7th Course "Challenges and Prospects of Nanomedicine
for Brain Targeting"
Course Director: Francesca Re
The INTERNATIONAL SCHOOL OF NANOMEDICINE has the pleasure to invite you to attend the course “Nanofluidics, Nanoimaging and Nanomanipulation” that will be held on 5-11 April 2018 at International “ETTORE MAJORANA FOUNDATION AND CENTRE FOR SCIENTIFIC CULTURE” of ERICE (Sicily) Italy.
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The course is co-organized with the Nanomedicine Center of the University Milano-Bicocca - NANOMIB
The course focuses on the state-of-the-art techniques and advanced biophysical methods related to Nanomedicine.
The Scientific Program includes the following topics:
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Nanofluidics: i) Nanopores, ii) Nanofluidics, iii) Microfluidics
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Nanoimaging: i) STED and PALM, ii) FLIM-STICS, iii) Light sheet microscopy
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Nanomanipulation: i) AFM, ii) Magnetic Tweezers, iii) Optical Tweezers
The course will provide many opportunities for interactions and discussions between students, postdocs, junior as well as senior investigators, encouraging and promoting networking between them. The Course will be located in the old pre-mediaeval city of Erice providing an amazing setting for high intellectual endeavor.
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We encourage Early Career Researches to present their investigations by submitting an abstract for either oral or poster presentation.
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The great Sicilian hospitality is aimed at forging collaboration and exploring ideas though multidisciplinary approaches.
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Directors of the Course
Giuseppe Chirico and Francesco Mantegazza (Università' di Milano-Bicocca & NANOMIB, Milano, Italy)
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Directors of the School
Mauro Ferrari (Houston Methodist Research Institute, USA) and Massimo Masserini (Università' di Milano-Bicocca & NANOMIB, Milano, Italy)
List of Invited Speakers:
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Marco Capitanio, European Laboratory for Non-Linear Spectroscopy (LENS), IT
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Alberto Diaspro, Istituto Italiano di Tecnologia (IIT), IT
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Sergi Garcia-Manyes, King's College London (KCL), UK
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Maria Garcia-Parajo, The Institute of Photonic Sciences (ICFO), ES
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Alessandro Grattoni, Houston Methodist Research Institute (HMRI), USA
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Malgorzata Lekka, The Institute of Nuclear Physics (PAN), PL
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Amit Meller, Technion - Israel Institute of Technology, IL
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Fernando Moreno-Herrero, Centro de Nacional de Biotecnologia (CNB-CSIC), ES
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Hyung Gyu Park, Nanoscience for Energy Technology and Sustainability (ETH-Zurich), CH
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Gian Michele Ratto, Istituto Nanoscienze Consiglio Nazionale delle Ricerche (CNRNANO), IT
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Thomas Schmidt, Leiden University, NL​
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Terence Strick, Institut Jacques Monod, FR
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Day 1 - THURSDAY April 5th, 2018
ARRIVALS ALL DAY
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Day 2 - FRIDAY April 6th 2018
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09.00-09.10 Welcome
G. Chirico and F. Mantegazza (Course Directors, Università' di Milano-Bicocca & NANOMIB, Milano, Italy)
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Session Chair: A. Meller (Technion - Israel Institute of Technology, Haifa, Israel)
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09.10-10.00 A. Grattoni (Houston Methodist Research Institute, USA)
“Stepping-down to the ultra-nanoscale: unexpected molecular transport under confinement”
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10.00-10.50 A. Grattoni (Houston Methodist Research Institute, USA)
“Biomedical applications of nanofluidics”
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10.50-11.10 A. Katranidis (Forschungszentrum Juelich, Germany)
“Following translation and folding of single proteins in real-time using optical tweezers”
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11.10-11.40 Coffee Break + Poster Session
11.40-12.30 H.G. Park (ETH-Zurich, CH)
“Nanofluidics under Graphitic Confinement”
12.30-12.50 O. Ström (Lund University, Sweden)
“DNA Separation and Purification using Microfluidics ”
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12.50-15.00 Lunch + free time
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Session Chair: H.G. Park (ETH-Zurich, CH)
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15.00-15.50 A. Meller (Technion - Israel Institute of Technology, Haifa, Israel)
“Nanopores for nanomedicine 1”
15.50-16.10 S.M.M. Dadfar (Karlsruhe Institute of Technology, Germany)
“Design and manufacturing of nanobiosensors suitable for protein detection”
16.10-16.30 T. Ma (University of Montpellier, France)
“Combining Light-Gated and pH-responsive nanopore based on PEG-spiropyran functionalization”
16.30-16.50 F. Ciceri (Mad City Labs, Zurich, CH)
“Modular Microscopy Systems for Single Molecule Imaging”
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16.50-17.20 Coffee Break + Poster Session
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17.20-18.10 T. Strick (Institut Jacques Monod, Paris, France)
"Introduction to Magnetic Tweezers and their application"
18.10-18.30 S. Dinarelli (Istituto di Struttura della Materia, CNR, Rome, Italy)
“Erythrocyte’s aging in microgravity condition”
18.30-18.50 R. Öz (Chalmers University of Technology, Goteborg, Sweden)
“A Nanofluidic Device for Real-Time Visualization of DNA-Protein Interactions on the Single DNA Molecule Level”
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Day 3 - SATURDAY April 7th 2018
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Session Chair: T. Schmidt (Leiden University, Netherlands)
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09.00- 09:50 H.G. Park (ETH-Zurich, CH)
“Nanofluidics across 2D Materials”
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09.50-10.40 M. Lekka (Dept. of Biophysical Microstructures, Kraków, Poland)
“Theoretical approaches describing mechanical properties of cells studied by AFM”
10.40-11.00 C. Scielzo​ (Ospedale San Raffaele, Segrate, Italy)
“HS1 role in regulating mechanical properties of Chronic Lymphocytic Leukaemia cells”
11.00-11.30 Coffee Break + Poster Session
11.30-12.20 A. Meller (Technion - Israel Institute of Technology, Haifa, Israel)
“Nanopores for nanomedicine 2”
12.20-12.40 Y. Tuna (Max-Planck-Institute, Erlangen, Germany)
“Micropipette geometry-induced electrostatic trapping of nanoparticles”
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12.40-15.00 Lunch + free time
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Session Chair: M. Lekka (Dept. of Biophysical Microstructures, Kraków, Poland)
15.00-15.50 T. Schmidt (Leiden University, Netherlands)
“Single-molecule microscopy for the visualization of signaling pathways”
15.50-16.10 A. Del Valle (IMDEA Nanoscience, Madrid, Spain)
“Simultaneous AFM nanoindentation and fluorescence microscopy of soft materials and individual bacteria”
​16.10-16.30 B. Holmes (JPK Instruments AG, Berlin, Germany)
“Atomic Force Microscopy in Conjunction with Super-Resolution Optical Microscopy On Living Cells”
16.30-16.50 A. Gennerich (Albert Einstein College of Medicine, New York, USA)
“Single-Molecule Dissection of Cytoplasmic Dynein Tension Sensing”
16.50-17.20 Coffee Break + Poster Session
17.20-18.10 T. Strick (Institut Jacques Monod, Paris, France)
"Magnetic Tweezers for the study of DNA transcription and repair"
18.10-18.30 C. Arbore (University of Florence, Italy)
“Force Sensing and Response by a Single Alpha-catenin Molecule Inside and Outside the Cadherin-catenin Complex”
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Day 4 - SUNDAY April 8th 2018
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Session Chair: G. Chirico (University of Milano-Bicocca & NANOMIB, Milano, Italy)
09.00-09.50 T. Schmidt (Leiden University, Netherlands)
“Mechanosensing and mechanotransduction in cancer”
09.50-10.40 M. Garcia-Parajo (The Institute of Photonic Sciences, Barcelona, Spain)
“Introduction to nanophotonics & applicability to Biology”
10.40-11.00 F. Bardelli (CNR-Nanotec, Lecce, Italy)
“Combining synchrotron radiation phase-contrast and fluorescence nano-tomographies to obtain high resolution 3D imaging and elemental distribution and quantification of biological tissue”
11.00-11.30 Coffee Break + Poster Session
11.30-12.20 M. Lekka (Dept. of Biophysical Microstructures, Kraków, Poland)
“Experiment and applications of AFM in nanomechanics of living cells”
12.20-14.00 Lunch + free time
14.00 Excursion to Segesta Archeological Park (Contrada Barbaro, 91013 Calatafimi TP) and to Castellammare del Golfo (TP)
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Day 5 - MONDAY April 9th, 2018
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Session Chair: M. Garcia-Parajo (The Institute of Photonic Sciences, Barcelona, Spain)
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09.00-09.50 S. Garcia-Manyes (King's College London, UK)
“Single molecule force spectroscopy AFM: fundamentals and challenges”
09.50-10.40 F. Moreno-Herrero (Centro de Nacional de Biotecnologia, Madrid, Spain)
“Introduction to AFM imaging and its application to study nucleic acids structure and DNA-protein interactions”
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​10.40-11.00 R. Corti (University of Milano-Bicocca & NANOMIB, Monza, Italy)
“Single-Molecule Force Spectroscopy of Metastable Structures of α-Synuclein Induced by Dopamine and EGCG”
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11.00-11.30 Coffee Break + Poster
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11.30-12.20 M. Capitanio (LENS, Florence, Italy)
“Single Molecule High-Resolution Measurements with Optical Tweezers”
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12.20-12.40 P. Bondia (IMDEA nanoscience, Madrid, Spain)
“Correlative AFM and fluorescence microscopy of amyloid fibers: structural characterization and light-induced damage”
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12.40-15.00 Lunch + free time
Session Chair: F. Moreno-Herrero (Centro de Nacional de Biotecnologia, Madrid, Spain)
15.00-15.50
S. Garcia-Manyes (King's College London, UK)
​ “Linking mechanochemistry and protein folding with single bond resolution”
15.50-16.40 G. M. Ratto (Istituto Nanoscienze CNR, Pisa, Italy)
“A window with a view: visualizing brain function and pathology by two photon microscopy”
​16.40-17.00 P. Campbell (University of Dundee, UK)
“Optically controlled microbubble cavitation: A route to understanding ultrasound driven drug delivery using ultrafast framing cameras”
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17.00-17.30 Coffee Break + Poster
17.30-18.20 A. Diaspro (Istituto Italiano di Tecnologia, Genova, Italy)
“Basics and Advances in Super resolved fluorescence microscopy”
18.20-18.40 M. Bouzin (Università' di Milano-Bicocca & NANOMIB, Milano, Italy)
“A Fluorescence-based Particle Sorter for the Isolation of
Pathogens at Ultra-Low Concentration”
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20.30 Social dinner at Caffé San Rocco, Via Gian Filippo Guarnotti, 23, Erice
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​ Day 6 - TUESDAY April 10th, 2018
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Session Chair: T. Strick (Institut Jacques Monod)
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09.00-09.50 F. Moreno-Herrero (Centro de Nacional de Biotecnologia, Madrid, Spain)
“Combined Magnetic Tweezers – TIRF microscopy and applications”
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09.50-10.40 M. Garcia-Parajo (The Institute of Photonic Sciences, Barcelona, Spain)
“Photonic antennas for nanoscopy & fluorescence correlation spectroscopy at the nanoscale”
10.40-11.00 M. Cristofalo (University of Milano-Bicocca & NANOMIB, Monza, Italy)
“Combined Role of DNA-Binding Protein H-NS and Macromolecular Crowding on Bacterial Nucleoid Organization: a Single-Molecule Study”
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11.00-11.30 Coffee Break + Poster
11.30-12.20 M. Capitanio (LENS, Florence, Italy)
“Probing Molecular Motors Movements and DNA-binding Proteins with Optical Tweezers and Fluorescence Microscopy”
12.20-15.00 Lunch + free time
Session Chair: F. Mantegazza (University of Milano-Bicocca & NANOMIB, Milano, Italy)
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15.00-15.50 A. Diaspro (Istituto Italiano di Tecnologia, Genova, Italy)
“Liquid Tunable Microscopy: converging technologies and label free methods for a new paradigm microscopy”
15.50-16.10 M. Collini (Università' di Milano-Bicocca & NANOMIB, Milano, Italy)
“Spatio-temporal Image Correlation as a powerful tool to study complex diffusion regimes in cellular environments”
16.10-16.30 G. Cozzi (Nikon, Italy)
“Exploring the Nanoscale with N-STORM 5.0”
16.30-16.50 F. Radaelli (Università degli Studi di Milano-Bicocca, Milano, Italy)
“μMAPPS: a novel phasor approach to second harmonic analysis for in vitro-in vivo investigation of collagen microstructure”
16.50-17.20 Coffee Break + Poster
17.20-18.10 G. M. Ratto (Istituto Nanoscienze CNR, Pisa, Italy)
“Optical functional imaging of the brain and data analysis: a story about numbers and more numbers”
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​​​Day 7 - WEDNESDAY APRIL 11th, 2018
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Departure from Erice
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POSTER VIEWING and DISCUSSIONS
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(every day during coffee breaks)
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SCIENTIFIC PROGRAM
